药物血浆蛋白结合率增高多见于病理状态,但减低却不常见。本实验观察地塞米松对哌嗪唑与血浆蛋白结合的影响。实验动物用新西兰兔,分3个剂量组,每组连续3天给地塞米松,在每天给药后24h 及第3天给药后48h取血4次。用体外平衡透析法测定哌嗪唑与血浆蛋白 Drug plasma protein binding increased more common pathological state, but reduced is not common. The experiment observed dexamethasone piperazine and plasma protein binding. New Zealand white rabbits were divided into 3 groups, each group was treated with dexamethasone for 3 consecutive days. Blood samples were obtained 4 and 48 hours after dosing at 24 and 3 days after administration. Determination of piperazole and plasma proteins by in vitro equilibrium dialysis