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[目的]探讨奥氮平联合草酸艾司西酞普兰对老年冠心病合并抑郁症状患者的疗效.[方法]选自本院于2014年3月至2017年3月期间收治的老年冠心病合并抑郁症患者106例,按照随机数表法分为观察组与对照组各53例.对照组给予奥氮平片治疗,观察组在对照组基础上结合草酸艾司西酞普兰片治疗.两组疗程均为24周.比较两组治疗疗效,治疗前后抑郁自评量表(SDS)评分和汉密尔顿抑郁量表(HAMD)评分、血同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平、氧化应激指标及生活质量各量表评分变化.[结果]观察组治疗总有效率(92.45%)高于对照组(73.58%),差异有显著性(P<0.05).两组治疗后SDS评分和HAMD评分均降低(P<0.05),且观察组更低于对照组(tSDS=9.7886、tHAMD=16.4589,P<0.05).两组治疗后血清Hcy和hs-CRP水平也均降低(P<0.05),且观察组更低于对照组(tHcy=11.3279、ths-CRP=12.8047,P<0.05).两组治疗后血清丙二醛(MDA)水平降低而超氧化物歧化酶(SOD)水平增加(P<0.05);观察组治疗后血清MDA水平低于对照组而SOD水平高于对照组(tMDA=13.8751、tSOD=5.2982,P<0.05).两组治疗后社会关系、心理状态、生理健康和周围环境评分增加(P<0.05),且观察组评分高于对照组(t=5.6586、7.7935、8.2064、8.3707,P<0.05).[结论]氮平联合草酸艾司西酞普兰对老年冠心病合并抑郁症状患者疗效明显,具有重要研究价值.“,”[Objective]To investigate the efficacy of olanzapine combined with oxalic acid Ai Sciplan in the treatment of senile coronary heart disease(CHD)accompanied with depressive symptoms.[Methods]A total of 106 elderly patients with coronary heart disease complicated with depression admitted from March 2014 to March 2017 in our hospital were randomly divided into an observation group(53 cases)and a control group (53 cases).The control group was treated with Olanzapine Tablets,and the observation group was treated with Escitalopram Oxalate Tablets on the basis of the control group.The two groups were treated for 24 weeks.The therapeutic effects of the two groups were compared.The scores of SDS and HAMD,Hcy and hs-CRP,indexes of oxidative stress and quality of life were evaluated before and after treatment.[Results] The total effective rate of the observation group(92.45%)was higher than that of the control group(73.58%)(P<0.0).The SDS score and HAMD score decreased in the two groups after treatment,and the observation group was lower than the control group(t SDS=9.7886、t HAMD=16.4589,P <0.05).After treatment,the ser-um Hcy and hs-CRP levels of the two groups were decreased(P <0.05),the observation group was lower than that of the control group(t Hcy= 11.3279、t hs-CRP= 12.8047,P < 0.05);the serum malondialdehyde (MDA)levels in the two groups decreased and the superoxide dismutase(SOD)levels increased after treat-ment,(P <0.05);the level of serum MDA in the observation group was lower than that in the control group,while the level of SOD was higher than that in the control group(t MDA=13.8751、t SOD=5.2982,P <0.05);aftertreatment,social relations,psychological status,physical health and the surrounding environment score of the two groups increased(P <0.05),and the observation group score were higher than the control group(t = 5.6586、7.7935、8.2064、8.3707,P <0.05).[Conclusion] Olanzapine combined with oxalic acid Ai Sciplan is effective in the treatment of elderly coronary heart disease patients with depression,and has impor-tant research value.