目的 :研究进口青霉素V钾片在健康人体的药物动力学。方法 :12名健康男性受试者 ,空腹单剂口服进口青霉素V钾片 15 0 0mg ,采用微生物法测定不同时间血清中药物浓度 ,用 3P87软件经微机处理血药浓度 -时间数据。结果 :用药后体内过程符合二房室开放模型 ,其主要药动学参数如下 ,达峰时间 (Tmax)为 (0 70± 0 .11)h ,峰浓度 (Cmax)为 (12 86± 2 2 6 )mg/L ,消除半衰期 (t1/ 2 β)为 (1 2 7± 0 2 4)h ,药时曲线下面积 (AUC)为 (2 0 30±2 90 )mg·h·L-1。结论 :进口青霉素V钾片药动学特点可为临床用药提供参数依据。 Objective: To study the pharmacokinetics of imported penicillin V potassium tablets in healthy volunteers. Methods: Twelve healthy male subjects were orally administered with a single dose of penicillin V potassium 150 mg orally. The concentration of the drug in serum at different time was determined by the microbiological method. The plasma concentration-time data were processed by the computer with 3P87 software. RESULTS: The in vivo process was in accordance with the two-compartment open model. The main pharmacokinetic parameters were as follows: peak time (Tmax) was (0 70 ± 0.11) h and peak concentration (Cmax) was (12 86 ± 2 2 6 , the elimination half-life (t1 / 2 β) was (12 ± 0 2 4) h, and the area under the curve (AUC) was (20 30 ± 2 90) mg · h · L -1. Conclusion: The pharmacokinetic characteristics of imported penicillin V potassium tablets can provide the basis for clinical use.