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目的 分析脑梗死、脑出血、短暂脑缺血发作 (TIA和VBI)患者血清中S 1 0 0B蛋白和神经元特异性烯醇化酶 (NSE)的动态变化 ,探讨它们在急性脑血管病发病中的临床意义。方法 选择病史、症状、体征及CT、MRI检查符合脑梗死、脑出血、短暂脑缺血发作的住院患者共 91例 ,取发病 4 8、72h和 7d的静脉血 ,用ELISA法和放免法测定血清S 1 0 0B蛋白和NSE水平 ,并分别与正常对照组比较。结果 脑梗死和脑出血组的S 1 0 0B蛋白和NSE血清浓度与短暂脑缺血发作及对照组比较明显升高 (P <0 .0 5 ,P <0 .0 1 )。S 1 0 0B蛋白与梗死 /出血体积以及神经系统功能缺损评分呈正相关 ,NSE含量仅与梗死体积和神经系统功能缺损评分呈正相关 ,与出血体积无明显相关性。短暂脑缺血发作组患者的S 1 0 0B蛋白和NSE含量无明显变化。结论 S 1 0 0B蛋白可以反映脑梗死和脑出血病情变化的程度 ,NSE仅能反映脑梗死患者的病情变化 ;两者对短暂脑缺血发作患者没有病情预测作用
Objective To analyze the dynamic changes of S100B protein and neuron specific enolase (NSE) in serum of patients with cerebral infarction, cerebral hemorrhage and transient ischemic attack (TIA and VBI), and to explore their dynamic changes in the pathogenesis of acute cerebrovascular disease The clinical significance. Methods A total of 91 inpatients with cerebral infarction, cerebral hemorrhage and transient ischemic attack were selected according to their medical history, symptoms and signs, and CT and MRI. Venous blood samples were taken at 4, 8, 72 and 7 days after the onset of symptoms. ELISA and radioimmunoassay Serum S100B protein and NSE levels, respectively, and compared with the normal control group. Results The serum levels of S100B protein and NSE in cerebral infarction and intracerebral hemorrhage were significantly higher than those in transient ischemic attack and control group (P <0.05, P <0.01). There was a positive correlation between the S100B protein and the infarction / hemorrhage volume and the neurological deficit score. The NSE content was only positively correlated with the infarct volume and the nervous system dysfunction score, but not with the bleeding volume. There was no significant change in the S100B protein and NSE content in patients with transient ischemic attack. Conclusion S 100B protein can reflect the degree of change of cerebral infarction and intracerebral hemorrhage. NSE can only reflect the change of disease in patients with cerebral infarction. Both of them have no predictive value in patients with transient ischemic attack