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众所周知,若用抗原或致有丝分裂因子刺激T 细胞时,则IL-2 R 可出现于细胞膜表面。1985年Nelson 等首次报告,IL-2 R 不仅出现于细胞膜表面,且出现于培养上清液和血液中,称之为可溶性IL-2R。他们认为,用PHA 刺激的正常人末梢血淋巴细胞的培养上清及感染HTLV-Ⅰ的T 细胞系的培养上清中的高价可溶性IL-2 R,和细胞膜表面的IL-2 R 共同存在。这表明它可成为活化T 细胞的标记物。此后,发现ATL、T细胞瘸及Hodgkin 病的血清中也存在IL-
It is well known that IL-2R may appear on the surface of cell membranes when T cells are stimulated with antigens or mitogenic agents. In 1985, Nelson et al. First reported that IL-2R not only appeared on the surface of cell membrane, but also appeared in culture supernatant and blood, which was called soluble IL-2R. They think that the high soluble soluble IL-2 R in the culture supernatant of normal human peripheral blood lymphocytes stimulated with PHA and in the culture supernatant of the T cell line infected with HTLV-I coexists with IL-2 R on the surface of the cell membrane. This shows that it can be a marker of activated T cells. Since then, it has been found that ATL, T cell lame and Hodgkin’s disease serum IL-