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目的研究nm23-H1蛋白在乳腺癌中的表达及临床意义。方法应用免疫组化法对87例乳腺癌患者标本中nm23-H1蛋白的表达进行检测。结果nm23-H1蛋白阳性表达率为51.72%,nm23-H1表达与淋巴结状态、组织学分级、临床分期及术后生存期有关(P<0.05),nm23-H1蛋白的表达与年龄、肿瘤大小、ER的表达无明显关系(P>0.05)。结论nm23-H1的表达可能与乳腺癌的发展及预后有关;nm23-H1蛋白的表达对判断乳腺癌进展及预后有一定的参考价值。
Objective To study the expression of nm23-H1 protein in breast cancer and its clinical significance. Methods The expression of nm23-H1 protein in 87 breast cancer samples was detected by immunohistochemistry. Results The positive expression rate of nm23-H1 was 51.72%. The expression of nm23-H1 was correlated with lymph node status, histological grade, clinical stage and postoperative survival (P <0.05). The expression of nm23-H1 was correlated with age, tumor size, ER expression was not significantly related (P> 0.05). Conclusion The expression of nm23-H1 may be related to the development and prognosis of breast cancer. The expression of nm23-H1 may be useful for judging the progression and prognosis of breast cancer.