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氨酚喹是一种4-氨基喹啉类药物。50年代初作为氯喹的替代药用于疟疾。其代谢物去乙基氨酚喹的杀虫机理与氯喹杯似,对氯喳抗性株的早期研究曾提示使用氨酚喹会产生交叉抗性,但是近来更多的临床研究发现氨酚喹对泰国和东非的氯喹抗性株有效,并已被恶性疟原虫抗氯喹株体外敏感性测试所证实。氨酚喹在英国已使用30年,但销路不大,随着上述研究工作的进展,人们对氨酚喹又
Paracetamol is a 4-aminoquinoline drug. Early 50s as a chloroquine alternative medicine for malaria. Its metabolite de-estrogen quinoline has a pesticidal mechanism similar to that of chloroquine, and early studies of clofazon resistant strains have suggested that paracetamol will produce cross-resistance, but more recent clinical studies have shown that paracetamol It is effective against chloroquine resistant strains in Thailand and East Africa and has been confirmed by an in vitro susceptibility test against Plasmodium falciparum chloroquine resistant strains. Paracetamol has been used in the United Kingdom for 30 years, but sales are not large. With the progress of the above research work,