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目的探讨氨溴索不同给药途径对新生儿胎粪吸入性肺炎的疗效。方法选取揭西县棉湖华侨医院2012年6月至2015年6月收治的150例新生儿胎粪吸入性肺炎患儿,随机均分为两组。两组患儿均行综合疗法,观察组在此基础上给予氨溴索雾化吸入;对照组在综合疗法基础上给予氨溴索静脉泵入。记录比较两组患者的生命体征与临床症状;比较两组1个疗程后疗效及疗程内不良反应情况。结果观察组住院时间、吸痰次数、湿啰音消失时间、发绀消失时间、呼吸困难改善时间及血氧饱和度恢复时间均显著优于对照组(P<0.01);观察组总有效率为94.67%,对照组为88.00%,差异未见统计学意义(P>0.05);两组不良反应发生情况比较差异未见统计学意义(P>0.05)。结论新生儿胎粪吸入性肺炎采取氨溴索雾化吸入疗法的疗效切实、安全性更好,值得推广。
Objective To investigate the effect of different administration routes of ambroxol on neonatal meconium aspiration pneumonia. Methods 150 cases of neonates with meconium aspiration pneumonia admitted at Huaqiao Overseas Chinese Hospital of Jiexi County from June 2012 to June 2015 were randomly divided into two groups. The two groups of children were treated with combination therapy, the observation group was given inhalation of ambroxol; the control group was given ambroxol intravenously on the basis of comprehensive therapy. The vital signs and clinical symptoms of the two groups were compared and recorded. The curative effect and adverse reactions during the course of treatment were compared between the two groups. Results The length of hospital stay, number of sputum aspirates, disappearance of wet rales, disappearance of cyanosis, improvement of dyspnea and recovery time of oxygen saturation in observation group were significantly better than those in control group (P <0.01). The total effective rate in observation group was 94.67 %, While the control group was 88.00%, the difference was not statistically significant (P> 0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Neonatal meconium aspiration pneumonia with ambroxol inhalation therapy is effective, safe and worthy of promotion.