异常的血管新生是指在原有血管的基础上形成新生血管的过程,依赖于促血管生成因子和抑制血管生成因子之间的调控失衡,其参与糖尿病肾病的病理过程,如肾小球肥大、肾小球毛细血管基底膜增厚、毛细血管通透性增加。实验证明血管内皮生长因子及内皮抑素对异常血管新生的发展起着重要的作用。现介绍近年来异常的血管新生与糖尿病肾病的研究的进展。 Abnormal angiogenesis refers to the process of forming new blood vessels on the basis of the original blood vessels, and is dependent on the imbalance between the regulation of angiogenic factors and the inhibition of angiogenic factors. The abnormal angiogenesis is involved in the pathological processes of diabetic nephropathy such as glomerulus hypertrophy and kidney Pelvic capillary basement membrane thickening, increased capillary permeability. Experiments show that vascular endothelial growth factor and endostatin on the development of abnormal angiogenesis plays an important role. Now introduced in recent years, abnormal angiogenesis and diabetic nephropathy research progress.