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干扰素(IFN)具有抗病毒作用,临床上已用于治疗慢性乙型肝炎。IFN 通过激活2′,5′-寡腺苷合成酶(2-5AS)发挥其抗病毒作用。因此,该酶可作为估价 IFN 疗效的客观指标。但 IFN 对不同慢性乙型肝炎病人的2-5AS 的诱导差异很大。作者对21例经肝活检病理确诊的 HBsAg 阳性慢性乙型肝炎患者应用IFN 治疗,观察其外周血单核细胞(PBMC)表面IFN 受体数量和亲和力的变化,及其与2-5AS 活力的关系,并探讨了这种差异的机制。病人和方法 21例患者分为2组:第1组14例,其中慢性迁延性肝炎(CPH)6例,慢性活动性肝炎(CAH)7例,肝硬化1例,每日肌注 IFNα或 IFNβ
Interferon (IFN) has antiviral effect, has been used clinically to treat chronic hepatitis B. IFN exerts its antiviral effect by activating 2 ’, 5’-oligoadenosine synthase (2-5AS). Therefore, the enzyme can be used as an objective measure of efficacy of IFN. However, the induction of 2-5AS by IFN differs greatly among patients with different chronic hepatitis B patients. The author of 21 cases of HBsAg-positive chronic hepatitis B confirmed by pathology of liver biopsy patients with IFN treatment, observe the peripheral blood mononuclear cells (PBMC) surface IFN receptor number and affinity changes, and 2-5AS vitality , And explored the mechanism of such differences. Patients and Methods Twenty-one patients were divided into two groups: group 1, 14 patients, including 6 patients with chronic persistent hepatitis (CPH), 7 patients with chronic active hepatitis (CAH), 1 patient with cirrhosis, and daily intramuscular IFNα or IFNβ