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由9-咔唑乙酸和二丁基氧化锡反应制得了新配合物{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征,用X射线单晶衍射测定了配合物的晶体和分子结构。该配合物晶体属于单斜晶系,C2/c空间群,晶胞参数a=2.797 5(13)nm,b=2.153 4(10)nm,c=1.515 4(7)nm,β=118.759(6)°,V=8.003(7)nm3,Z=4,μ=1.285 mm-1,Dc=1.386 g/cm3,F(000)=3 408,R=0.0571,wR=0.136 2,GOF=1.005。结构测定表明,它具有以Sn2O2四元环为中心,中心对称的二聚体结构。内、外环Sn原子均为五配位的畸变三角双锥构型。生物活性测试结果表明,该配合物对体外培养的乳腺癌细胞株MCF-7和结肠癌细胞株WiDr有较好的抑制活性。
The new complex {[(n-C4H9) 2Sn (0.5 · O2CCH2C12H8N) (0.5 · C2H5O)] 2O} 2 · (C12H8NH) was prepared by the reaction of 9-carbazoleacetic acid with dibutyltin oxide. Its structure was characterized by elemental analysis, IR and 1HNMR. The crystal and molecular structure of the complex were determined by X-ray single crystal diffraction. The complex crystal belongs to the monoclinic space group C2 / c with a = 2.797 5 (13) nm and b = 2.153 4 (10) nm, c = 1.515 4 (7) nm and β = 118.759 D = 1.386 g / cm3, F (000) = 3 408, R = 0.0571, wR = 0.136 2, GOF = 1.005 . The structural determination shows that it has a central symmetrical dimer structure centered on the Sn2O2 four-membered ring. The inner and outer ring Sn atoms are five-coordinated distorted triangular double cone configuration. The biological activity test results showed that the complex has good inhibitory activity on cultured MCF-7 breast cancer cell line and colon cancer cell line WiDr.