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目的观察护肝宁片联合多烯磷脂酰胆碱治疗药物性肝损伤的临床疗效。方法选择2012年6月-2014年6月于医院就诊的药物性肝损伤患者120例,随机分为治疗组和对照组各60例,2组患者均给予常规的内科治疗,对照组在常规治疗的基础上加用多烯磷脂酰胆碱治疗,治疗组在对照组治疗的基础上加用护肝宁片治疗,观察2组患者治疗前后肝功能指标的变化和临床疗效。结果治疗前2组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)及血清总胆红素(TBi L)比较差异无统计学意义(P>0.05)。治疗后2组患者的ALT、AST及TBi L指标均较治疗前降低,且治疗组低于对照组;治疗后治疗组的总有效率为83.3%高于对照组的61.7%,差异均有统计学意义(P<0.05)。结论护肝宁片联合多烯磷脂酰胆碱治疗药物性肝损伤疗效确切,可改善肝功能指标,值得推广应用。
Objective To observe the clinical efficacy of Huganing Tablets combined with polyene phosphatidylcholine in the treatment of drug-induced liver injury. Methods 120 patients with drug-induced liver injury in our hospital from June 2012 to June 2014 were randomly divided into treatment group (60 cases) and control group (60 cases). The two groups were given conventional medical treatment. The control group received routine treatment Based on the use of polyene phosphatidylcholine treatment, the treatment group in the control group based on the treatment with Huganing film treatment, observation of two groups of patients before and after treatment of liver function changes and clinical efficacy. Results There was no significant difference in ALT, AST and TBiL between the two groups before treatment (P> 0.05). After treatment, the ALT, AST and TBi L indexes of two groups were lower than those before treatment, and the treatment group was lower than the control group; the total effective rate of the treatment group was 83.3% higher than that of the control group (61.7%), the difference was statistically Significance (P <0.05). Conclusion Huganing tablets combined with polyene phosphatidylcholine treatment of drug-induced liver injury curative effect is exact, can improve liver function indicators, it is worth promoting the application.