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目的 针对腔隙性脑梗死多基因致病的特点 ,进行人类白细胞抗原 (HLA) DQA1等位基因分型 ,分析腔隙性脑梗死的遗传易感性。方法 采用聚合酶链反应 序列特异性引物 (PCR SSP)联合技术对 6 2例腔隙性脑梗死患者及 6 4名正常对照组进行HLA DQA1等位基因的基因分型。结果 HLA DQA1 0 30 1基因频率在腔隙性脑梗死组明显高于正常对照组 ,原发性高血压阳性家族史的患者组明显高于具有阴性家族史的患者组 ,而DQA1 0 10 3基因频率在正常对照组却明显增高。结论 HLA DQA1 0 30 1基因与腔隙性脑梗死的遗传易感性相关 ,与具有原发性高血压阳性家族史患者的腔隙性脑梗死的发病相关 ;HLA DQA1 0 10 3基因可能是腔隙性脑梗死的保护性基因。
Aim To investigate the multi-gene pathogenicity of lacunar infarction, HLA DQA1 alleles were genotyped to analyze the genetic predisposition of lacunar infarction. Methods Genotyping of HLA DQA1 alleles was performed in 62 patients with lacunar infarction and 64 normal controls using polymerase chain reaction sequence specific primers (PCR SSP). Results The frequencies of HLA DQA1 0 30 1 gene in lacunar infarction group were significantly higher than those in normal control group. The patients with positive family history of hypertension were significantly higher than those with negative family history. The frequency of DQA1 0 10 3 gene Frequency in the normal control group was significantly higher. Conclusion The HLA DQA1 0 30 1 gene is associated with the genetic susceptibility to lacunar infarction and is associated with the pathogenesis of lacunar infarction in patients with a positive family history of hypertension. The HLA DQA1 0 10 3 gene may be a gap Protective gene of cerebral infarction.