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蓝萼甲素在浓度0.1～100μmol·L~(-1)时可抑制A23187刺激的免血小板生成血小板活化因子,其IC_(50)为0.47μmol·L~(-1),当其浓度为10,100μmol·L~(-1)时能抑制花生四烯酸诱导的兔血小板血栓素A_2生成同时升高前列腺素E_2,推测蓝萼甲素通过抑制血小板活化因子生物合成及选择性抑制血栓素A_2生成而抑制血小板激活。
PC12 inhibited platelet-derived platelet-activating factor stimulated by A23187 at a concentration of 0.1-100 μmol·L -1, with an IC 50 value of 0.47 μmol·L -1 at a concentration of 10,100 μmol·L -1 could inhibit arachidonic acid-induced thromboxane A 2 production and increase the content of prostaglandin E 2 in rabbits. It was speculated that the blue calmodulin could inhibit thromboxane A 2 production by inhibiting the biosynthesis of platelet-activating factor While inhibiting platelet activation.