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目的观察联合应用地高辛与美托洛尔控制持续性心房颤动(房颤)心室率的疗效和安全性。方法44例持续性房颤患者,应用地高辛0.25mg/d治疗1周后,随机分为两组,一组维持原治疗1周,另一组联合美托洛尔25～50mg/d治疗1～2周,观察两组治疗前后静息心室率、活动后心率及不良反应。结果美托洛尔联用地高辛组治疗前及治疗后2周静息心室率分别为(95.6±17.6)次/min及(75.3±8.3)次/min,降低幅度21.2%(P<0.05)。活动后心室率由用药前(171.1±22.4)次/min降至(154.0±19.8)次/min,降低幅度17.1%。未见不良反应。单用地高辛治疗者的静息心室率有所下降,但运动后的快速心室率无改变。结论美托洛尔与地高辛合用可更有效的控制房颤的心室率。
Objective To observe the efficacy and safety of digoxin combined with metoprolol in controlling ventricular rate of persistent atrial fibrillation (AF). Methods Forty-four patients with persistent AF were treated with digoxin (0.25 mg / d) for 1 week and then were randomly divided into two groups. One group maintained for 1 week and the other combined metoprolol 25 to 50 mg / d One to two weeks later, the resting ventricular rate, heart rate and adverse reactions were observed before and after treatment. Results The ventricular rate of metoprolol combined with digoxin before treatment and 2 weeks after treatment were (95.6 ± 17.6) times / min and (75.3 ± 8.3) times / min, respectively, with a decrease of 21.2% . After the activity, the ventricular rate decreased from (171.1 ± 22.4) times / min to (154.0 ± 19.8) times / min, with a decrease of 17.1%. No adverse reactions. Resting ventricular rate decreased with digoxin alone, but there was no change in fast ventricular rate after exercise. Conclusion Metoprolol and digoxin can be more effective in controlling ventricular rate of atrial fibrillation.