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钙调神经磷酸酶(calcineurin,CaN)是Ca2+的下游因子,在细胞内钙升高引起的心肌肥大中有重要作用。现综述Ca2+CaN及其下游因子活化T细胞核因子3(NFAT3)和锌指转录因子(GATA4)在心肌肥大中的作用及近年的研究进展。
Calcineurin (CaN) is a downstream factor of Ca2 + and plays an important role in cardiac hypertrophy induced by elevated intracellular calcium. We reviewed the role of Ca2 + CaN and its downstream factors activated T-cell nuclear factor 3 (NFAT3) and zinc finger transcription factor (GATA4) in myocardial hypertrophy and recent research progress.