论文部分内容阅读
目的 :探讨尼莫地平 (nimodipine)对动脉压力感受器反射的影响。方法 :2 0例 ASA I～ II级、拟在全麻下施行胆囊切除手术的患者 ,随机分为尼莫地平组 (NM组 )和对照组 (C组 ) ,每组 10例。在麻醉前及麻醉手术开始后分别静注新福林或硝酸甘油进行加压试验或减压试验。观察用药前后血压、心率的变化。用心动周期和动脉收缩压变化量的线性回归斜率来反映动脉压力感受器反射敏感度。结果 :在 C组患者 ,加压反射的斜率由麻醉前的 89.1m s/k Pa降到麻醉手术期的 46 .9ms/ k Pa(P<0 .0 5 ) ,减压反射的斜率由麻醉前的 81.9m s/ k Pa降到麻醉手术期的 36 .7ms/ k Pa(P<0 .0 5 ) ;NM组患者 ,加压反射和减压反射的斜率分别由麻醉前的 5 5 .9ms/ k Pa和 5 7.4m s/ k Pa降到麻醉手术期的 31.2 ms/ k Pa和 2 3.5 ms/ k Pa(均 P<0 .0 5 ) ;NM组患者在麻醉前、麻醉手术期的加压反射和减压反射的斜率与 C组患者比较均有轻微的降低 ,但无统计学显著性。结论 :小剂量尼莫地平对动脉压力感受器反射有轻度抑制作用。临床常用剂量的尼莫地平应用于麻醉手术期是安全的
Objective: To investigate the effect of nimodipine on arterial baroreceptor reflex. Methods: Twenty cases of ASA I ~ II were enrolled in this study. Patients undergoing cholecystectomy under general anesthesia were randomly divided into nimodipine group (NM group) and control group (C group), with 10 cases in each group. Before anesthesia and anesthesia after the start of intravenous injection of new Fulin or nitroglycerin pressure test or decompression test. Observed before and after treatment of blood pressure, heart rate changes. The linear regression slope of cardiac cycle and arterial systolic pressure was used to reflect the reflex sensitivity of the arterial baroreceptors. Results: In group C, the slope of pressure reflex decreased from 89.1 ms / kPa before anesthesia to 46.9 ms / kPa during anesthesia (P <0.05), and the slope of decompression reflex was 81.9ms / kPa to anesthesia 36.7ms / kPa (P <0.05). In the NM group, the slopes of pressure reflex and decompression reflex were respectively changed from 559ms / kPa and 5 7.4ms / kPa decreased to 31.2 ms / kPa and 23.5 ms / kPa respectively (all P <0.05). Before anesthesia, anesthesia was performed in NM group The slopes of reflex and decompression reflexes were slightly lower than those in group C, but not statistically significant. Conclusion: A small dose of nimodipine has a mild inhibitory effect on arterial baroreceptor reflex. Clinical dosage of nimodipine for anesthesia surgery is safe