研究旨在应用记录肾传入神经多单位和单位放电的方法 ,观察肾动脉内注射L 精氨酸对麻醉家兔肾神经传入纤维自发放电活动的影响。结果表明 :( 1)肾动脉内注射L 精氨酸 ( 0 0 5、0 2 4和 0 48mmol/kg)可呈剂量依赖性地抑制肾传入纤维的活动 ,而动脉血压不变 ;( 2 )静脉内预先注射一氧化氮合酶抑制剂L NAME ( 0 11mmol/kg) ,可完全阻断L 精氨酸对肾传入纤维的抑制 ;( 3 )肾动脉注射一氧化氮 (NO)供体SIN 1( 3 .75 μmol/kg)也可抑制肾传入神经的活动。以上结果提示 :肾动脉内应用NO前体L 精氨酸和NO供体SIN 1均可抑制肾传入纤维的自发活动 The aim of this study was to investigate the effect of intrarenal injection of L-arginine on the spontaneous firing activity of renal afferent nerve fibers in anesthetized rabbits. The results showed that: (1) Injection of L-arginine into renal artery (0 05,024 and 0 48 mmol / kg) could inhibit renal afferent fibers in a dose-dependent manner, while arterial blood pressure did not change; (2 ) Intravenous pre-injection of nitric oxide synthase inhibitor L NAME (0 11mmol / kg), can completely block the inhibition of L-arginine on renal afferent fibers; (3) renal artery injection of nitric oxide (NO) Body SIN 1 (3.75 μmol / kg) also inhibits renal afferent activity. The above results suggest that: NO administration of L-arginine and NO donor SIN 1 in renal artery can inhibit the spontaneous activity of renal afferent fibers