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目的观察比索洛尔治疗扩张型心肌病(DCM)充血性心力衰喝的临床疗效。方法32例患者均在常规强心、利尿、血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮杭剂(ARB)治疗基础上,加用比索洛尔治疗6个月。6个月治疗前、后检查超声心动图各项指标及测量血压、心率变化结果并比较。结果治疗6个月后心功能改善Ⅱ级20例,改善I级8例,总有效率为87.5%,超声心动图示:左室收缩末内径(LVESD)较用药前缩小(P<0.01),左室射血分数(LVEF)、左室短轴缩短率(FS)较治疗前显著增高(P<0.01),治疗后心率减慢、血压下降(P<0.01),差异性有统计学意义,未见毒副反应发生。结论扩张型心肌病合并充血性心力衰竭患者在常规治疗基础上联用比索洛尔可使临床症状及心功能改善,安全可靠。
Objective To observe the clinical efficacy of bisoprolol in the treatment of dilated cardiomyopathy (DCM) congestive heart failure. Methods Thirty-two patients were treated with bisoprolol for 6 months on the basis of conventional cardiotomy, diuretic, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonist (ARB). 6 months before and after treatment, check echocardiography various indicators and measure blood pressure, heart rate changes and compare results. Results After 6 months of treatment, cardiac function improved in 20 cases of grade Ⅱ and improved in 8 cases of grade Ⅰ, the total effective rate was 87.5%. Echocardiography showed that LVESD decreased (P <0.01) Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (FS) were significantly higher than those before treatment (P <0.01). After treatment, heart rate slowed down and blood pressure decreased (P <0.01), the difference was statistically significant No toxic side effects occurred. Conclusions Dilated cardiomyopathy combined with bisoprolol in patients with congestive heart failure can improve the clinical symptoms and cardiac function and be safe and reliable.