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目的：探讨老年脑梗塞患者外周血肿瘤坏死因子（ＴＮＦ）、内皮素—１（ＥＴ—１）和心钠素（ＡＮＰ）含量变化及其临床意义。方法：采用放射免疫法测定３０例老年人脑梗塞急性期和２７例健康老年人的外周血ＴＮＦ、ＥＴ—１、ＡＮＰ水平。结果：老年人脑梗塞急性期外周血ＴＮＦ（１．２５±０．３８ｍｇ／ｍｌ）、ＥＴ—１（１０８．４±６．５ｐｑ／ｍｌ）和ＡＮＰ（２１８．９５±２４．３５ｐｑ／ｍｌ）水平明显高于对照组，有统计学意义（Ｐ＜０．０１），增高的程度与病情、病灶大小有关。ＴＮＦ与ＥＴ—１、ＡＮＰ呈显著正相关（ｒ＝０．５４７和０．６２９，Ｐ＜０．０１）。结论：ＴＮＦ、ＥＴ—１和ＡＮＰ可能同时参与了老年人急性脑梗塞的发病过程。ＴＮＦ诱发ＥＴ—１、ＡＮＰ，测定ＴＮＦ可作为脑梗塞病情轻重的重要指标之一。
Objective: To investigate the changes of tumor necrosis factor (TNF), endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) in peripheral blood of elderly patients with cerebral infarction and its clinical significance. Methods: The peripheral blood levels of TNF, ET-1 and ANP in 30 elderly acute cerebral infarction and 27 healthy elderly were measured by radioimmunoassay. Results: The peripheral blood levels of TNF (1.25 ± 0.38mg / ml), ET-1 (108.4 ± 6.5pq / ml) and ANP (218.95 ± 24.35pq / ml) The level was significantly higher than the control group, with statistical significance (P <0.01), the extent of the increase with the disease, the size of the lesion. There was a significant positive correlation between TNF and ET-1 and ANP (r = 0.547 and 0.629, P <0.01). Conclusion: TNF, ET-1 and ANP may participate in the pathogenesis of acute cerebral infarction in the elderly. TNF-induced ET-1, ANP, determination of TNF can be used as one of the important indicators of severity of cerebral infarction.