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T 细胞的特异性激活需要特异性 T 细胞受体(TCR)/CD3复合物信号,同时还需要共刺激信号.现已证实,在 CD40-CD40-L 和 B7-CD28/CTLA-4(CDl52)二条共刺激途径中,CD28,CFLA-4和 ICOS 与其配体 B7家族分子(B7.1/CD80和B7.2/CD86)结合后所产生的共刺激信号(costimulatory signal)在 T 细胞活化过程中起重要作用.迄今,国内外开展有关肝移植排异、原发性胆汁性肝硬变和原发性硬化性胆管炎等自身免疫疾病、血吸虫等寄生虫感染、HCV 病毒感染、肿瘤、重症肝炎中肝损伤 T 细胞的特异性激活共刺激研究,但乙肝病毒感染所致的肝损伤 T 细胞的特异性激活共刺激研
Specific activation of T cells requires specific T cell receptor (TCR) / CD3 complex signals and co-stimulatory signals are also required It has been demonstrated that CD40-CD40-L and B7-CD28 / CTLA- In the two co-stimulatory pathways, the costimulatory signal produced by the binding of CD28, CFLA-4 and ICOS to their ligand B7 family molecules (B7.1 / CD80 and B7.2 / CD86) during T cell activation So far, at home and abroad to carry out on liver transplant rejection, primary biliary cirrhosis and primary sclerosing cholangitis and other autoimmune diseases, parasites such as schistosome infection, HCV virus infection, cancer, severe hepatitis Specific activation of T cells in liver injury co-stimulated study, but specific activation of liver injury T cells caused by hepatitis B virus infection co-stimulated