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The primary cultured human aorta smooth muscle cells(SMCs)were characterized and theeffects of all—trans retinoic acid(atRA)on these cells were analysed.It is found that atRA could slowdown the growth rate of SMCs,and decrease the expression Ievels of cyclinDl,CDK4,c-myc at39％。38％and 43.6％respectively,while atRA had no effects on the expression of c~-actin which isspecific for SMCs.Results demonstrated that atRA inhibited cell growth of SMCs but did not induce celIdifferentiation.These effects may be clue to the decreased translation Ievels of cyclinDl.CDK4 andtranscription Ievel of c-myc.The fact that ati tA inhibited SMCs proIiferation may become one of thetheoretic basis for the cIinicaI use of atRA in the trea㈣t of SMCs proliferative diseases such asatherosclerosis.
The primary cultured human aorta smooth muscle cells (SMCs) were characterized and the effects of all-trans retinoic acid (atRA) on these cells were analysed. It is found that atRA could slow down the growth rate of SMCs, and decrease the expression Ivels of cyclin D1 , CDK4, c-myc at39%. 38% and 43.6% respectively, while atRA had no effects on the expression of c ~ -actin which isspecific for SMCs.Results demonstrated that atRA inhibited cell growth of SMCs but did not induce cIlifferentiation. These effects may be clue to the reduction translationIevels of cyclinDl.CDK4 and transcription Ievel of c-myc.The fact that ati tA inhibited SMCs proIiferation may become one of the theoretic basis for the cIinicaI use of atRA in the trea ivt of SMCs proliferative diseases such asatherosclerosis.