How to reduce interference among neighbor nodes in wireless mesh networks is still an important and key issue nowadays. In this paper, an optimized channel assignment algorithm(OCA) is proposed to solve this problem based on link throughput and node priority. The effects of the numbers of network interface cards and channels on the network throughput are analyzed and evaluated. When there are seven of the numbers of both network interface cards and channels, the efficiency of utilizing network interface card and channel reaches highest. Compared with centralized channel assignment algorithm(CCA), the proposed algorithm has less packet loss rate and more network throughput significantly. How to reduce interference among nodes in wireless mesh networks is still an important and key issue nowadays. In this paper, an optimized channel assignment algorithm (OCA) is proposed to solve this problem based on link throughput and node priority. numbers of network interface cards and channels on the network throughput are evaluated and evaluated. When there are seven of the numbers of both network interface cards and channels, the efficiency of utilizing network interface card and channel reaches highest. CCA), the proposed algorithm has less packet loss rate and more network throughput significantly.