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目的 分析多发性骨髓瘤肾脏损害的临床特征及其发生的相关因素。方法 对多发性骨髓瘤患者肾脏损害的临床表现及实验室检查进行统计学分析。结果 肾脏损害的发生率为 3 9 1% ( 18/4 6) ,以慢性肾功能不全最常见。骨髓浆细胞数量和尿BJP与肾功能损害之间有显著相关关系 (P <0 0 0 5 ;P <0 0 1) ,贫血及多发性骨损害与肾脏损害有相关关系 (P <0 0 5 )。结论 骨髓浆细胞增殖及尿链蛋白产生可能是多发性骨髓瘤肾脏损害的主要原因
Objective To analyze the clinical characteristics and related factors of renal damage in multiple myeloma. Methods The clinical manifestations of renal damage in patients with multiple myeloma and laboratory tests were statistically analyzed. Results The incidence of renal damage was 391% (18/46), with chronic renal insufficiency the most common. There was a significant correlation between the number of bone marrow plasma cells and urinary BJP and renal dysfunction (P <0.05 or P <0.01), and anemia and multiple bone damage were associated with renal damage (P <0.05 ). Conclusion The proliferation of plasma cells and the production of urinary protein in the marrow may be the main reason of multiple myeloma