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目的 研究影响Ⅲc期卵巢上皮癌长期生存的因素。方法 随访1988年1月～1994年1月间86例Ⅲc期卵巢癌患者至1999年1月(随访率为93.02％),观察了年龄、职业、文化程度、居住地、临床症状、初潮年龄、结婚年龄、初产年龄、产次、人流次数、末产年龄、绝经年龄、一般状态、血型、术前Hb值、AFP值、术前化疗、癌发部位、术中卵巢、输卵管状况、大网膜浸润、脏器表面浸润、术式、残留病灶、术中失血量、输血量、腹水量、术后诊断、分化程度、术后化疗时间、术后化疗方式、术后化疗次数等因素对Ⅲc期卵巢上皮癌预后的影响,应用Cox模型进行了多因素分析。结果 AFP值、术前化疗、年龄、居住地、残留病灶、失血量、腹水量、术后诊断、分化程度、一般状态、临床症状、术后化疗次数等15个因素进入了Cox模型。获得全局x~2=49.834、df=15、P<0.0001。结论 术后化疗次数、一般状态、居住地和年龄对Ⅲc期卵巢上皮癌长期生存的影响较大,提示临床医师应注重对Ⅲc期卵巢上皮癌术后的药物治疗。
Objective To study the factors affecting the long-term survival of stage Ⅲc epithelial ovarian cancer. Methods Totally 86 patients with stage Ⅲc ovarian cancer between January 1988 and January 1994 were followed up for January 1999 with a follow-up rate of 93.02%. The effects of age, occupation, educational level, residence, clinical symptoms, menarche age, Marital age, primiparous age, birth time, number of abortions, end of life, menopausal age, general status, blood type, preoperative Hb value, AFP value, preoperative chemotherapy, cancerous sites, intraoperative ovarian, tubal status, Membranous invasion, invasion of organs, surgical procedures, residual lesions, intraoperative blood loss, blood transfusion, amount of ascites, postoperative diagnosis, differentiation, postoperative chemotherapy, postoperative chemotherapy, postoperative chemotherapy and other factors Ⅲc Stage ovarian cancer prognosis, using Cox model for multivariate analysis. Results AFP values, preoperative chemotherapy, age, residence, residual disease, blood loss, amount of ascites, postoperative diagnosis, differentiation, general status, clinical symptoms, postoperative chemotherapy and other 15 factors into the Cox model. Get the global x ~ 2 = 49.834, df = 15, P <0.0001. Conclusions The frequency of postoperative chemotherapy, general status, residence and age have a great influence on the long-term survival of stage Ⅲc epithelial ovarian cancer, suggesting that clinicians should pay attention to the postoperative drug treatment of stage Ⅲc ovarian epithelial cancer.