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目的研究精准腹腔热灌注化疗在胃癌D2手术中的应用效果。方法 63例胃癌D2手术患者,随机分为观察组(43例)和对照组(20例)。两组均行常规治疗,观察组在此基础上加用精准腹腔热灌注化疗,对照组行5-氟尿嘧啶(5-Fu)灌注化疗。对比两组患者临床表现及治疗效果。结果观察组术后胃癌腹膜种植转移及局部复发率为6.98%,不良反应发生率为13.95%,分别低于对照组的30.00%、70.00%,差异具有统计学意义(P<0.05)。结论精准腹腔热灌注化疗可以减缓、削弱化疗操作的毒副作用及影响,降低复发、不良反应发生率,在医疗效果方面的利好影响显著。
Objective To study the effect of precise intraperitoneal hyperthermic perfusion chemotherapy in D2 operation of gastric cancer. Methods Sixty-three D2 patients with gastric cancer were randomly divided into observation group (43 cases) and control group (20 cases). Conventional treatment was performed in both groups. The observation group was treated with precise intraperitoneal hyperthermic perfusion chemotherapy, and the control group was treated with 5-fluorouracil (5-Fu) perfusion chemotherapy. The clinical manifestations and treatment effects of the two groups of patients were compared. Results The rate of postoperative gastric cancer peritoneal metastasis and local recurrence in the observation group was 6.98%, and the incidence of adverse reactions was 13.95%, which was lower than that of the control group 30.00% and 70.00% respectively. The difference was statistically significant (P<0.05). Conclusion Accurate intraperitoneal hyperthermic perfusion chemotherapy can slow down and weaken the side effects and effects of chemotherapy, reduce the incidence of recurrence and adverse reactions, and have a significant effect on the medical effect.