细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)是由Bouhon等在20世纪90年代初期发现的一类丝氨酸/苏氨酸蛋白激酶,是有丝分裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)家族的重要亚族之一[1]。活化的ERK能将胞外刺激信号传递至胞核,从而调节基因的表达,参与细胞增殖、分化、迁移、侵袭和凋亡等多种生物学效应。近年来研究发现ERK信号通路在肾脏疾病的发生、发展过程中起着重要的作用。因此,本文将对ERK信号通路与肾脏疾病的研究进展予 Extracellular signal-regulated kinase (ERK) is a type of serine / threonine protein kinase discovered by Bouhon et al. In the early 1990s. It is a mitogen-activated protein kinase (MAPKs) One of the most important subfamilies of the family [1]. Activated ERK can signal extracellular stimuli to the nucleus, thereby regulating the gene expression, involved in cell proliferation, differentiation, migration, invasion and apoptosis and other biological effects. In recent years, studies have found that ERK signaling pathway plays an important role in the occurrence and development of kidney disease. Therefore, this article will be on the ERK signaling pathway and renal disease research progress