S100蛋白家族是一类非泛素化、EF-手型钙结合蛋白,通过与钙离子及靶蛋白的相互作用,在体内发挥多种生物学作用,参与细胞周期活动、细胞分化、肿瘤生长以及细胞外基质分泌活动等过程。其分布具有细胞、组织特异性。其中多个成员在肿瘤中表达异常,并与肿瘤的增殖、浸润转移和凋亡密切相关,其中包括S100A6。S100A6又称为钙周期蛋白(Calcyclin,Cacy),过去也称为2A9、5810、PRA和CACY。 The S100 protein family is a non-ubiquitinated, EF-type calcium-binding protein that exerts a variety of biological effects in vivo through its interaction with calcium ions and target proteins and is involved in cell cycle activity, cell differentiation, tumor growth, and Extracellular matrix secretion activity and other processes. Its distribution with cells, tissue-specific. Many of them are abnormally expressed in the tumor and are closely related to tumor proliferation, invasion and metastasis and apoptosis, including S100A6. S100A6, also known as Calcyclin (Cacy), formerly known as 2A9, 5810, PRA and CACY.