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以ＨＳＶ－１接种人单核细胞系Ｕ９３７和小鼠腹腔巨噬细胞，通过病毒感染滴度测定，间接荧光抗体试验检测病毒抗原及多聚酶链反应检测病毒基因，在体外实验中研究了单核巨噬细胞对ＨＳＶ－１的抗性及其影响因素。结果证实，Ｕ９３７和小鼠腹腔巨噬细胞均能逐步清除ＨＳＶ－１，从感染中恢复；１０～２０μｇ／ｍｌＬＰＳ处理细胞能削弱细胞的抗性、促进病毒基因表达，而５μｇ／ｍｌＢＣＧ能增强细胞的抗性、加速病毒的灭活和清除。
HSV-1 was used to inoculate human monocytic cell line U937 and mouse peritoneal macrophages. The virus titer was determined by virus titer, indirect fluorescent antibody test was used to detect the viral antigen and the polymerase chain reaction was used to detect the virus gene. Resistance of HSCs to macrophage and its influencing factors. The results confirmed that both U937 and mouse peritoneal macrophages can gradually clear HSV-1 and recover from infection. Cells treated with 10 ~ 20μg / ml LPS can weaken cell resistance and promote viral gene expression, while 5μg / mlBCG can enhance cells Resistance to accelerate virus inactivation and clearance.