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用放免法测定了２８名内科急症中多器官衰竭（ＭＯＦ）患者的血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡＴ－Ｄ）和醛固酮（ＡＬＤ）水平。结果：ＭＯＦ患者的ＡＴ－Ⅱ及ＡＬＤ均较对照组明显升高（两组分别为１５５．８０±７７．００ｎｇ／Ｌ，１４８．０９±６６．００ｎｇ／Ｌ与６６．５３±１６．２０ｎｇ／Ｌ，１０２．４６±３２．６０ｎｇ／Ｌ），Ｐ＜０．０１；ＰＲＡ及ＡＬＤ随衰竭器官数增多而升高，而ＡＴ－Ⅱ则随衰竭器官数增多而降低；死亡组ＡＴ－Ⅱ水平明显低于存活组（分别为７２．３７±２４．４４ｎｇ／Ｌ与１７４．０１±８２．２８ｎｇ／Ｌ），Ｐ＜０．０１。提示肾素－血管紧张素系统参与了ＭＯＦ的发病过程。作者认为测定内科ＭＯＦ患者的ＰＲＡ、ＡＴ－Ⅱ、ＡＬＤ对病情监测及预后判断有一定价值。
The plasma renin activity (PRA), angiotensin Ⅱ (AT-D) and aldosterone (ALD) levels in 28 patients with multiple organ failure (MOF) were determined by radioimmunoassay. Results: The levels of AT-Ⅱ and ALD in MOF patients were significantly higher than those in control group (155.80 ± 77.00ng / L, 148.09 ± 66.00ng / L and 66.53 ± 16.20ng / L, L, 102.46 ± 32.60ng / L), P <0.01; PRA and ALD increased with increasing numbers of failing organs and AT-Ⅱdecreased with increasing number of failing organs; (72.37 ± 24.44ng / L and 174.01 ± 82.28ng / L, respectively), P <0.01. Prompt renin - angiotensin system involved in the pathogenesis of MOF. The authors believe that the determination of medical MOF patients with PRA, AT-Ⅱ, ALD of disease monitoring and prognosis have some value.