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东茛菪碱五个剂量(1、2、5、10、20μg/ml作用于12名健康成人外周血淋巴细胞培养液诱发染色体畸变,并设空白对照组(生理盐水)。染色体畸变率分别为3.±0.5,9.6±1.1,11.7±1.1,13.6±2.3,18.0±3.0和17.5±2.0％;细胞畸变率为3.1±0.6,9.2±0.6,10.0±0.8,10.8±1.5,11.6±1.8和12.2±14.％。各剂量组与对照组比较差异高度显著(P<0.01)。方差分析,各剂量组间变异的差异高度显著(P<0.01)。相关系数和回归系数也非常显著(P<0.01)。结果表明,东莨菪碱剂量与染色体畸变率和细胞畸变率有线性关系。
Five doses of scopolamine (1, 2, 5, 10, and 20 μg/ml) were used to induce chromosome aberrations in peripheral blood lymphocyte cultures of 12 healthy adults, and a blank control group (physiological saline) was set up. Chromosome aberration rates were 3. ± 0.5, 9.6 ± 1.1, 11.7 ± 1.1, 13.6 ± 2.3, 18.0 ± 3.0 and 17.5 ± 2.0%; cell aberration rates 3.1 ± 0.6, 9.2 ± 0.6, 10.0 ± 0.8, 10.8 ± 1.5, 11.6 ± 1.8 and 12.2±14.% The difference between each dose group and the control group was highly significant (P<0.01), and variance analysis showed that the difference among the dose groups was highly significant (P<0.01), and the correlation coefficient and regression coefficient were also significant (P<0.01). <0.01) The results showed that there was a linear relationship between scopolamine dosage and chromosome aberration rate and cell aberration rate.