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４０例活动性十二指肠球部溃疡（ＤＵ）病人均伴有胃窦炎，２８例胃窦部幽门螺旋菌（ＨＰ）阳性，１２例阴性。基础胃酸分泌（ＢＡＯ）、五肽胃泌索刺激后的高峰胃酸分泌（ＰＡＯ）以及空腹和餐后１小时血清胃泌素水平，在ＨＰ（＋）组均明显高于ＨＰ（－）组（Ｐ＜０．０１～０．０２）。经治疗，１０例ＨＰ（＋）患者复查，发现ＨＰ清除后空腹和餐后血清胃泌素均显著下降（Ｐ＜０．０１），但平均ＢＡＯ和ＰＡＯ下降不明显（Ｐ＞０．０５）。研究结果提示，ＨＰ系通过刺激胃泌素分泌及胃酸增高而引起ＤＵ，ＨＰ清除后血清胃泌索下降，ＰＡＯ无明显下降。鉴于此，采用杀灭ＨＰ药物结合Ｈ２受体阻断剂治疗，可望加速溃疡愈合。
Forty patients with active duodenal ulcer (DU) were accompanied by antral gastritis, and 28 cases of gastric antrum were positive for Helicobacter pylori (HP), 12 were negative. Basal gastric acid secretion (BAO), peak gastric acid secretion (PAO) after pentagastrin stimulation and fasting and postprandial one hour serum gastrin levels in HP (+) group were significantly higher than those in HP (-) group P <0.01 ~ 0.02). After treatment, 10 cases of HP (+) patients were reviewed, fasting serum and postprandial serum gastrin were significantly decreased (P <0.01), but the average BAO and PAO decreased not significantly (P> 0.05) . The results suggest that, HP Department through the stimulation of gastrin secretion and increased gastric acid caused by DU, HP after removal of serum gastrin decreased, PAO no significant decline. In view of this, the use of anti-HP drugs combined with H2 receptor blocker therapy, is expected to accelerate ulcer healing.