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积雪草Centella asiatica对皮肤、精神、血液等疾病具有疗效,在印度传统草药中被广泛应用于精神病、癫痫、癔病。作者探讨了它对中枢神经系统的作用与机理。积雪草样品经乙醇渗漉,漉液于50℃以下真空浓缩至半固态(产率40％),再制成100mg/ml提取物的悬浮液,相当于250mg/ml生药。动物实验用Albino小鼠(18～25g)和Wistar大鼠(150～200g),雌雄均有,口服药物2和4h后进行观察。中枢镇静作用在戊巴比妥睡眠时间实验(45mg/kg i p)中,积雪草提取液使小鼠睡
Centella asiatica is effective against skin, mental and blood diseases and is widely used in Indian traditional herbs for psychosis, epilepsy, and rickets. The author explored its role and mechanism in the central nervous system. Centella asiatica samples were ethanol leached and the mash was concentrated under vacuum below 50°C to a semi-solid (yield 40%) and a 100 mg/ml suspension of the extract was produced, corresponding to 250 mg/ml crude drug. Animal experiments used Albino mice (18-25 g) and Wistar rats (150-200 g), both male and female, and were observed after oral administration for 2 and 4 h. Central sedative effect of pentobarbital sleep time test (45mg/kg i p), Centella asiatica extract mice sleep