论文部分内容阅读
目的探讨老年黄斑变性（ＡＲＭＤ）是否存在遗传因素。方法分析一个７姊妹兄弟的家族中，４位成员的老年黄斑变性患病情况。结果在被检查的６位６０岁以上的姊弟中，３位男性均患ＡＲＭＤ，且其中２姊弟为湿性型，其线粒体脱氧核糖核酸（ｍｔＤＮＡ）均呈突变。虽然这些成员长期生活在不同国家和环境，却有类似的临床或实验室改变。结论从本家族ＡＲＭＤ发病情况看，ＡＲＭＤ发病机制上可能存在遗传因素
Objective To investigate the genetic factors of age-related macular degeneration (ARMD). Methods Analyze the prevalence of age-related macular degeneration among four members of a family of seven siblings. Results Of the 6 children over the age of 60 who were examined, all three men had ARMD, and 2 of them were wet and had a mutation in their mitochondrial deoxyribonucleic acid (mtDNA). Although these members have long lived in different countries and environments, they have similar clinical or laboratory changes. Conclusion From the incidence of ARMD in this family, there may be genetic factors in the pathogenesis of ARMD