Sp1 regulates primordial folliculogenesis through Notch2-dependent pathways in mouse

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：kimleetj007

【摘要】

：

【作者】

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Han Cai Huarong Wang Chao Wang Guoliang Xia

【机构】

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State Key Laboratory of Agro biotechnology,College of Biological Sciences,China Agricultural Univers

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

【关键词】

：

Sp1 primordial folliculogenesis Notch2

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　　Establishment of the pool of primordial follicles each consisting of an oocyte surrounded by a layer of somatic cells is essential for mammalian fertility.However,very little is known about the breakdown of germ-cell nests and formation of primordial follicles.Previously,only few factors such as Notch2,Jagged1 and NOBOX are associated with this process.In our study,Specificity protein 1(Sp1),a zinc-finger transcription factor that regulates multiple cellular functions was found to be essential for the mouse primordial follicle formation.

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Sp1 regulates primordial folliculogenesis through Notch2-dependent pathways in mouse

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