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Telomeres are significant structures at the end of chromosomes,which play an essential role in various biological events,such as aging and apoptosis.In recent years,the research on telomeres and telomerase is a hot topic in life science.The human telomeric-DNA sequence consists of double stranded dTTAGGG/dCCCTAA repeats and a guanine-rich single-stranded 3’overhang that can fold into intramolecular G-guadruplex structures,which block the action of telomerase.As telomerase is activated to maintain the length of telomere in 80-85％ of cancer cells and stablization of G-quadruplexes by small molecules has recently shown to inhibit the transcriptional activity of some oncogenes,G-quadruplex has become an important and promising approach for developing anticancer drugs.