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目的回顾性分析伊曲康唑注射液治疗血液系统恶性肿瘤继发侵袭性真菌感染(IFI)疗效及安全性。方法入选我院血液科收治的血液系统恶性肿瘤伴发IFI患者69例,用伊曲康唑注射液200 mg,q12 h,疗程超过14 d,评价其疗效及安全性。结果痊愈或显效60例(87.0%);出现不良反应13例(18.8%),其中9例(70%)为用药14 d前发生。结论长程用伊曲康唑注射液疗效明确,安全性较好。
Objective To retrospectively analyze the efficacy and safety of itraconazole injection in the treatment of secondary invasive fungal infection (IFI) in hematological malignancies. Methods Sixty-nine patients with malignant hematological malignancies and IFI were enrolled in our department of hematology. The patients were treated with itraconazole 200 mg q12 h for more than 14 days to evaluate their efficacy and safety. The results were cured or markedly effective in 60 cases (87.0%); adverse reactions in 13 cases (18.8%), of which 9 cases (70%) occurred 14 d before treatment. Conclusion Long-term use of itraconazole injection has clear effect and good safety.