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目的观察来氟米特联合糖皮质激素治疗慢性肾小球肾炎的效果。方法选取2013年9月-2015年9月医院接收肾小球肾炎患者78例,随机分为对照组和试验组各39例,对照组接受传统治疗,试验组接受来氟米特联合糖皮质激素治疗,对治疗效果及过程中不良反应发生情况作出统计。结果 2组患者经过临床治疗后,临床症状均得到显著缓解,且治疗过程中,2组患者出现的不良反应差异不大,但对照组患者肌酐、尿素、尿蛋白等指标恢复情况不及试验组,差异具有统计学意义(P<0.05)。结论将来氟米特联合糖皮质激素应用于慢性肾小球肾炎患者的临床治疗中,可以有效患者患者症状,且用药安全性较高。
Objective To observe the effect of leflunomide combined with glucocorticoid on chronic glomerulonephritis. Methods Seventy-eight patients with glomerulonephritis admitted to our hospital from September 2013 to September 2015 were randomly divided into control group and experimental group with 39 cases each. The control group received conventional therapy. The experimental group received leflunomide plus glucocorticoid Treatment, the treatment effect and the incidence of adverse reactions to make statistics. Results After treatment, the clinical symptoms of both groups were significantly relieved. There was no significant difference in adverse reactions between the two groups in the course of treatment. However, the recovery of indicators such as creatinine, urea and urine protein in the control group was not as good as that in the experimental group, The difference was statistically significant (P <0.05). Conclusions The combination of leflunomide and glucocorticoids in the clinical treatment of patients with chronic glomerulonephritis can effectively treat the symptoms of patients and the medication is safe.