The essay aims at analyzing several main characters of The Human Stain written by Philip Roth from the perspective of existentialism,thus revealing the inevitable tragic destiny of modern people in a world filled with hypocrisy,persecution and distrust and the way to escape from the grievance and struggle in inner mind. The essay aims at analyzing several main characters of The Human Stain written by Philip Roth from the perspective of existentialism, thus revealing the inevitable tragic destiny of modern people in a world filled with hypocrisy, persecution and distrust and the way to escape from the grievance and struggle in inner mind.