论文部分内容阅读
目的探讨乳腺导管内乳头状病变的临床病理特征及其鉴别诊断。方法对64例乳腺导管内乳头状病变进行HE染色和CK5/6、p63、CK8、ER免疫组化染色观察。结果导管内乳头状瘤(IP)51例,伴不典型导管增生(ADH)或导管原位癌(DCIS)6例,导管内乳头状癌(IPC)4例,实性乳头状癌3例。32例伴普通型导管增生的IP其增生上皮CK5/6呈镶嵌状(+),CK8呈分散或簇状(+),其中21例ER呈不均匀(+);纤维血管轴心肌上皮呈p63和CK5/6(+)。导管内乳头状瘤伴ADH、IP伴DCIS、IPC和SPC的增生上皮CK5/6(-),CK8片状(+),ER均匀强(+);纤维血管轴心肌上皮呈p63和CK5/6(-)或(+)。结论乳腺导管内乳头状病变是一组良、恶性混合存在的病变,应通过特定的组织形态、增生上皮CK5/6、CK8和ER的表达情况以及肌上皮的位置进行鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of intraductal papillary lesions in breast. Methods 64 cases of intraductal papillary lesions were stained with HE and CK5 / 6, p63, CK8, ER immunohistochemical staining. Results There were 51 cases of intraductal papilloma (IP), 6 cases of atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS), 4 cases of intraductal papillary carcinoma (IPC) and 3 cases of solid papillary carcinoma. Among the 32 cases with normal ductal hyperplasia, their hyperplasia epithelium CK5 / 6 were inlaid (+), CK8 was scattered or clustered (+), of which 21 cases were inhomogeneous (+); fibrocytic axial myenteric epithelium p63 and CK5 / 6 (+). The hyperplastic epithelium CK5 / 6 (-), CK8 lamella (+) and ER were homogenous (+) in ductal papilloma with ADH, IP with DCIS, IPC and SPC. 6 (-) or (+). Conclusion Intraductal papillary papillary lesions are a group of benign and malignant mixed lesions that should be identified by specific tissue morphology, the expression of CK5 / 6, CK8 and ER, and the location of myoepithelial epithelial cells.