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目的：研究促甲状腺素释放激素（ＴＲＨ）和多巴胺（ＤＡ）伍用对失血性休克大鼠心肌收缩性能及存活时间的影响。方法：Ｗｉｓｔａｒ大鼠随机分成生理盐水（ＮＳ），ＴＲＨ，ＤＡ，ＴＲＨ＋ＤＡ４组，１０ｍｉｎ内放血至５．３ｋＰａ（４０ｍｍＨｇ），维持１．５ｈ，分别静脉给药治疗。结果：５ｍｇ／ｋｇＴＲＨ和１ｍｇ／ｋｇＤＡ单用能显著提高失血性休克大鼠平均动脉压（ＭＡＰ），升高左室收缩压（ＬＶＳＰ）和左室内压最大变化速率（±ｄｐ／ｄｔｍａｘ），延长存活时间。２．５ｍｇ／ｋｇＴＲＨ和０．２５ｍｇ／ｋｇＤＡ伍用有相似的改善心肌收缩性能、延长存活时间的作用，且稍优于两单用药组。结论：ＴＲＨ和ＤＡ配伍应用治疗失血性休克，可降低两单用药剂量，有一定的协同作用。
Objective: To study the effects of thyrotropin-releasing hormone (TRH) and dopamine (DA) on myocardial contractility and survival time in hemorrhagic shock rats. Methods: Wistar rats were randomly divided into normal saline (NS), TRH, DA and TRH + DA4 groups. Blood was bled to 5.3 kPa (40 mmHg) within 10 minutes and maintained for 1.5 hours. Results: 5mg / kg TRH and 1mg / kg DA alone could significantly increase mean arterial pressure (MAP), increase left ventricular systolic pressure (LVSP) and maximum left ventricular pressure (± dp / dtmax) in hemorrhagic shock rats Survival time. Both 2.5 mg / kg TRH and 0.25 mg / kg DA had similar effects of improving myocardial contractility and prolonging the survival time, which was slightly better than that of the two single-agent groups. Conclusion: The combination of TRH and DA in the treatment of hemorrhagic shock can reduce the dose of two single agents, and have certain synergistic effects.