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目的葛根素磷脂复合物的最佳工艺优化,并对其进行表征。方法以葛根素与磷脂的复合率为评价指标,采用正交实验设计考察了药物反应物的质量浓度、反应投料比和反应时间这三个因素对磷脂复合物的影响,并筛选最优制备工艺,并通过UV、IR和TLC分析技术对复合物结构进行分析。结果确定葛根素磷脂复合物的最佳制备工艺为:葛根素与磷脂的投料比为1:4(w/w),反应物质量浓度为80mg·m L~(-1),反应时间2 h,该工艺条件制备的磷脂复合物复合率为100%。结论葛根素磷脂复合物的形成受葛根素的质量浓度和投料比的影响较大,反应时间也有一定的影响,且在形成复合物的过程中并没有发生化学变化,但葛根素和磷脂间有一定的作用力,与单纯的物理混合不同。
Objective The optimal process of puerarin phospholipid complexes is optimized and characterized. Methods The composite ratio of puerarin and phospholipid was used as the evaluation index. The effects of the mass concentration of drug reactants, feed ratio of reaction and reaction time on phospholipid complex were investigated by orthogonal experimental design, and the optimal preparation process , And the complex structure was analyzed by UV, IR and TLC techniques. Results The optimum preparation conditions of puerarin phospholipid complex were as follows: the ratio of puerarin and phospholipid was 1: 4 (w / w), the concentration of the reaction was 80 mg · m L -1, the reaction time was 2 h The compounding ratio of the phospholipid complex prepared by the process conditions is 100%. Conclusion The formation of puerarin phospholipid complex is affected by the concentration of puerarin and the feeding ratio, and the reaction time also has a certain influence, and there is no chemical change during the formation of the complex, but there is between puerarin and phospholipid A certain force, different from purely physical mixing.