1971年从猪的下丘脑分离出促黄体生成素释放因子(LRF),确定为10肽结构,并于当年人工合成。由于还具有促滤泡刺激素释放的作用,所以称为促性腺激素释放激素(Go-nadotrophin releasing hormone,简称 Gn-RH)。此后相继出现了数百种兴奋性和抑制性衍生物,其中一些具有高效长效的性能,并广泛地进行了基础与临床研究,进展很快。本文对近年来在这方面的研究进展情况作一简要的综述。 Luteinizing hormone releasing factor (LRF) was isolated from the hypothalamus of pigs in 1971 and identified as a 10-peptide structure that was artificially synthesized in the current year. Because it also has the role of follicle-stimulating hormone release, so called gonadotropin releasing hormone (Go-nadotrophin releasing hormone, Gn-RH). Since then there have been hundreds of excitatory and inhibitory derivatives, some of which have long-lasting efficacies, extensive basic and clinical research, and rapid progress. This article gives a brief overview of the research progress in this area in recent years.