近年来广泛的研究资料表明,夫妇一方染色体异常是导致反复自然流产及娩出畸形儿的重要细胞遗传学因素。本文分析了遗传咨询中205对自然流产夫妇染色体,发现明显染色体畸变20例,报道如下。细胞遗传学检查1.材料和方法①资料来源本组205对夫妇中,流产2次130对,3次者55对,4次者13对,5次者6对,7次者2对,夫妇双方均进行外周血染色体分析。这些夫妇早期流产509次,晚期流产畸形12次,足月畸形儿1次。②方法显微镜下常规计数30个中期分裂相,G显带核型分析3～5个细胞,异常者显微摄影核型分析,并按人类染色体国际体制报告染色体核型。 In recent years, extensive research data show that one side of the couple chromosomal abnormalities is an important cytogenetic factor leading to repeated spontaneous abortion and delivery of deformed children. This article analyzes the genetic counseling 205 pairs of spontaneous abortion couples chromosomes, found that significant chromosomal aberrations in 20 cases, reported as follows. Cytogenetic examination 1. Materials and methods ① Data Source 205 couples in this group, 130 pairs of abortion 2 times, 3 times 55 pairs, 4 times 13 pairs, 5 times 6 pairs, 7 times 2 pairs, couples Peripheral blood chromosome analysis was performed on both sides. These couples early abortion 509 times, 12 cases of late abortion deformity, full-term deformity 1 child. ② Methods Normal dissection of 30 metaphase cells was observed under a microscope, and 3 to 5 cells of G-banding karyotype were analyzed. Photomicrography karyotype analysis of abnormalities was performed. Karyotypes were also reported according to the international system of human chromosomes.