波谱成像技术是MR功能成像的一种,它利用MR现象和化学位移作用,分析病灶特定原子核及其化合物分子代谢水平、代谢物浓度,从分子水平反映组织病理生理变化。目前应用于乳腺的波谱技术主要为1 H-MRS,其在乳腺癌的早期诊断、生物学评价、新辅助化疗早期疗效监测等方面具有独特的优势。本文从乳腺1 H-MRS的临床应用现状、技术限度与改进及前景展望等方面进行综述。 Spectroscopic imaging is a kind of MR imaging. It uses MR phenomenon and chemical shift to analyze molecular metabolism and metabolite concentration of specific nuclear and its compounds, and reflect the pathophysiological changes at the molecular level. Currently, the 1H-MRS technique is mainly applied to the diagnosis of breast, which has unique advantages in the early diagnosis of breast cancer, biological evaluation and early monitoring of the efficacy of neoadjuvant chemotherapy. This review summarizes the clinical application status, technical limitations and improvements of 1 H-MRS in breast and its prospects.