自从 Crossman1977年首次提出下丘脑-垂体-性腺-胸腺轴概念以来,神经内分泌网络学说受到广泛注意。中医肾藏精、主生殖,是生育功能的枢纽,这与神经内分泌网络的性腺轴的作用相似。近年来,中医肾本质的研究结果表明,肾包括神经内分泌和免疫等多种功能,而补肾法能调节下丘脑-垂体-性腺轴和免疫功能的紊乱。本文就此作了近十年来的文献综述。 Since the concept of the hypothalamus-pituitary-gonad-thymus axis first proposed by Crossman in 1977, the neuroendocrine network theory has received extensive attention. Traditional Chinese medicine, kidney essence and main reproduction, is the hub of fertility function, which is similar to the role of the gonadal axis of the neuroendocrine network. In recent years, studies on the kidney essence of Chinese medicine have shown that the kidney includes many functions such as neuroendocrine and immunity, and the kidney-building method can regulate the hypothalamus-pituitary-gonadal axis and the disorder of immune function. This article has made a review of the literature in the past decade.