目的探讨B族维生素对终末期肾病患者外周神经及自主神经病变的治疗作用。方法终末期肾病患者30例,行维持性血液透析及透析联合滤过治疗后,仍有外周神经及自主神经病变。给予维生素B1100 mg、B6100 mg、B12500μg,2次/周。同时常规血液透析,或透析联合滤过,治疗后4、8、12周评估患者外周神经、自主神经症状改善情况,感觉神经传导速度改善情况。结果经B族维生素治疗4周,患者临床症状、神经传导速度均较治疗前有明显改善(P<0.05),治疗后12周症状改善更为明显(P<0.01)。结论 B族维生素对尿毒症合并外周神经病变患者有明显治疗作用。 Objective To investigate the therapeutic effect of B vitamins on peripheral nerves and autonomic neuropathy in patients with end-stage renal disease. Methods Thirty patients with end-stage renal disease were treated by maintenance hemodialysis and dialysis combined with filtration. There were still peripheral nerves and autonomic neuropathy. Given vitamin B1100 mg, B6100 mg, B12500μg, 2 times / week. At the same time routine hemodialysis, or dialysis combined with filtration, 4,8,12 weeks after treatment evaluation of patients with peripheral nerves, autonomic symptoms, sensory nerve conduction velocity to improve the situation. Results After treatment with B vitamins for 4 weeks, the clinical symptoms and nerve conduction velocity were significantly improved (P <0.05), and the symptoms improved more significantly after 12 weeks of treatment (P <0.01). Conclusion B vitamins have significant therapeutic effect on uremic patients with peripheral neuropathy.