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豚鼠离体肺动脉用辣椒素（Ｃａｐｓａｉｃｉｎ）耗竭感觉神经肽（ＳＮＰ）后，缺氧性收缩反应（ＨＰＶ）显著增高（Ｐ＜０．０１）。套有带完整上皮支气管的肺动脉的ＨＰＶ显著弱于不套或套有去上皮支气管肺动脉的ＨＰＶ（Ｐ＜０．０５）；支气管与肺动脉同时用Ｃａｐ处理后，此差异消失；只有外套的支气管先用Ｃａｐ预处理时，肺动脉ＨＰＶ仍显著强于溶剂预处理的对照组（Ｐ＜０．０５）；套有去上皮支气管的肺动脉缺氧反应显著强于不套支气管的肺动脉。结果提示：肺动脉Ｃ－感觉神经所释放的ＳＮＰ在肺动脉缺氧反应中具调节作用；支气管上皮层可释放舒血管物质调节ＨＰＶ，此物质与ＳＮＰ密切相关；支气管还可能释放缩血管物质，介导ＨＰＶ。
Hypoxia contractile response (HPV) was significantly increased in isolated guinea pig pulmonary artery with capsaicin depletion of sensory neuropeptide (SNP) (P <0.01). The HPV of pulmonary artery with intact epithelial bronchus was significantly weaker than that of non-epithelial or exfoliated bronchopulmonary artery (P <0.05). When bronchial and pulmonary artery were treated with Cap at the same time, the difference disappeared. Only tunic bronchus Pulmonary artery HPV was still significantly stronger in the pretreatment with Cap (P <0.05) than that in the solvent pretreatment group. The pulmonary artery hypoxia response in deproteinized bronchial epithelium was significantly stronger than that in the bronchial-free pulmonary artery. The results suggest that the SNP released by pulmonary C-sensory nerves plays a regulatory role in the pulmonary hypoxia response. The bronchial epithelium can release vasorelaxant substances to regulate HPV, which is closely related to SNP. Bronchial may also release vasoconstrictors, mediating HPV.