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目的探讨幽门螺杆菌(Hp)感染、血清胃液素与胃癌发病的关系。方法对经内镜和病理检查证实的胃癌65例,取胃窦部粘膜组织1块,空腹静脉血测定Hp(1min尿素酶试验)和血清胃液素(放射免疫法)。另以30例Hp阴性慢性浅表性胃炎作为对照组。结果胃癌65例中20例Hp阳性(30.8%),血清胃液素均值83.05±23.95 ng/L,45例Hp阴性胃癌血清胃液素92.93±38.10 ng/L(P>0.05),其中12例胃体部癌和53例胃窦部癌血清胃液素为81.16±36.31 ng/L和91.69±30.65 ng/L(P>0.05)。30例慢性浅表性胃炎血清胃液素值122.16±39.74 ng/L明显高于胃癌组(P<0.01)。结论 Hp感染、血清胃液素水平与胃癌发生无明确关系。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection, serum gastrin and the incidence of gastric cancer. Methods Sixty-five patients with gastric cancer confirmed by endoscopy and pathological examination were enrolled. One piece of mucosal tissue was taken from the gastric antrum. Hp (1min urease test) and serum gastrin (radioimmunoassay) were measured in fasting venous blood. Another 30 patients with Hp negative chronic superficial gastritis served as a control group. Results Among the 65 cases of gastric cancer, 20 cases were positive for Hp (30.8%), serum gastrin levels were 83.05±23.95 ng/L, and 45 cases of Hp-negative gastric cancer were 92.93±38.10 ng/L (P>0.05), of which 12 cases were gastric body. The serum levels of serum gastrin were 81.16±36.31 ng/L and 91.69±30.65 ng/L in cancers and 53 cases of gastric antrum (P>0.05). In 30 patients with chronic superficial gastritis, the serum gastrin value was 122.16±39.74 ng/L, which was significantly higher than that in the gastric cancer group (P<0.01). Conclusion Hp infection and serum gastrin levels have no relationship with the occurrence of gastric cancer.