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生长抑素(somatostatin下称SS)是一种14肽激素,广泛分布于许多组织,具有多种生理作用.SS对胃肠道功能的影响已为人们所重视.产生SS细胞在胃肠道的分布含有SS的上皮细胞也称D细胞,存在于许多动物的消化道.人类胃肠道D细胞数从胃到下段结肠呈梯度减少.胃窦区D细胞数量极丰富.也见于胃腺及肠腺深部,主要在腺体底部1/3部位.D细胞小突的表面微绒毛与胃肠道腔接触,因此肠腔内容物,特别是氢离子和某些营养物的变化,可通过这种途径被D细胞感受而调节SS的分泌.SS既可分泌入胃肠壁组织间隙,由此进入静脉,也可直接进入胃肠腔内.在胃内,D细胞长而纤细的胞浆突起终止在G细胞和胃窦区的嗜铬细胞表面.在泌酸
Somatostatin (somatostatin, hereinafter referred to as SS) is a 14-peptide hormone, widely distributed in many tissues, with a variety of physiological effects.SS on gastrointestinal function has been paid attention to.Prevalence of SS cells in the gastrointestinal tract Distribution of SS-containing epithelial cells, also known as D cells, exist in many animals of the digestive tract.Human gastrointestinal D cell number from the stomach to the lower part of the colon was a gradient decrease.A large number of D-cells in the antrum area.Also found in the gastric glands and intestinal glands Deep, mainly in the bottom of the gland 1 / 3. D cell surface microvilli contact with the gastrointestinal tract, so the contents of the intestine, especially hydrogen ions and certain nutrients can be changed by this route Sense by the D cells to regulate the secretion of SS.SS can be secreted into the gastrointestinal wall tissue gap, thus entering the vein, but also directly into the gastrointestinal lumen in the D cell long and slender cytoplasmic processes termination G cells and antral parenchyma cell surface